Cameron Bruce Littlejohn represented Spartanburg County in the South Carolina House of Representatives from 1937 to 1943 and 1947 to 1949, the latter three years as Speaker. He resigned in 1949 when he won a judicial appointment. For the next thirty-five years, Littlejohn served on South Carolina's Seventh Circuit Court and the South Carolina Supreme Court, attaining the post of Chief Justice in his last two years on the Court.